NEW FROM REVOLUTION NMR!

Revolution NMR is developing, in cooperation with the University of Kansas, a multisample solids (MSS) probe which will provide a very significant improvement in spectrometer utilization for certain types of solid samples. The MSS probe is based on a concept patented by Eric Munson of the Department of Pharmaceutical Chemistry at the University of Kansas (US Patent 6,937,020) and the development program is partially funded by an STTR grant from the National Institutes of Health.

KU is currently testing a prototype MSS probe incorporating two of Revolution’s compact spinning modules. Figure 1 shows the two modules and associated hardware installed on the probe. Figure 2 shows the probe installed in a 300 MHz NMR attached to a linear actuator to reposition the spinning modules in the homogeneous region of the magnet. Two spectra are acquired sequentially by the two modules in the same amount of time that it would take to acquire a spectrum from one module. Both modules demonstrate excellent signal-to-noise and RF performance. The spectra of 3-methylglutaric acid (MGA) and hexamethyl benzene (HMB), acquired in this fashion, are shown below.

Figure 1	Figure 2

Revolution plans to begin delivering MSS probes in the first quarter of 2007. The MSS probe system will include:

• up to five spinning modules of any size, capable of operation at any one selected frequency from 200 to 400 MHz (contact us for higher fields and/or additional modules)
• a linear actuator capable of repositioning the probe in less than 1 sec.
• RF switches to allow the operation of multiple spinning modules with a single set of RF amplifiers
• speed controllers for each spinning module
• spectrometer interface and software for probe operation

To see a video of the prototype probe in operation please right-click to download the following Windows Media file: probe.wmv

Reference: Benjamin N. Nelson et al., "Multiple-sample probe for solid-state NMR studies of pharmaceuticals," Solid State Nuclear Magnetic Resonance 29 (2006), 204 – 213.

Please contact us for additional information.