MultiSample Solids Probe

Revolution NMR developed, in cooperation with the University of Kansas, a multisample solids (MSS) probe which will provide a very significant improvement in spectrometer utilization for certain types of solid samples. The MSS probe is based on a concept patented by Eric Munson and collaborators of the Department of Pharmaceutical Chemistry at the University of Kansas (US Patent 6,937,020) and the development program is partially funded by an STTR grant from the National Institutes of Health. An additional US patent 7,626,391, was recently granted on a two module version of the MSS probe.

The MSS probe has been fully tested and validated and is now commercially available from Revolution NMR. Revolution has delivered an MSS probe to Kansas Analytical Services LLC and has received its first commercial order. Figure 1 shows a typical four module MSS probe configuration. Each of the modules is electrically isolated and includes provisions for seperate spinning speed control. Signal to noise and 90 degree pulse times for each module are indentical to an individual probe.

Figure 1

Figure 2

The MSS probe system includes:

  • Up to four spinning modules of any size, capable of operation at any one selected frequency from 200 to 400MHz.
  • A linear actuator capable of repositioning the probe in less than 1 sec (not required for two module version).
  • RF switches to allow the operation of multiple spinning modules with a single set of RF amplifiers.
  • Custom electronics for spinning speed control, RF switching, and linear actuator control.
  • Spectrometer interface and software for probe operation.
  • Installation and training.
  • One year warranty.

To see a video of the prototype probe in operation please right-click to download the following Windows Media file: probe.wmv

Reference: Benjamin N. Nelson et al., "Multiple-sample probe for solid-state NMR studies of pharmaceuticals", Solid State Nuclear Magnetic Resonance 29 (2006), 204 - 213.

Please contact us for additional information.